In
biology, hybridization refers to the interaction of complementary nucleic acid
strands. Since DNA is a double-stranded structure held together by
complementary interactions (in which C always binds to G, and A to T),
complementary strands favorably reanneal or “hybridize” to each other when separated.
Hybridization can occur between two DNA strands and also between DNA and RNA
strands provided there is sufficient complementarity in their base sequence. DNA
denaturation, also called DNA melting, is the process by which double-stranded
deoxyribonucleic acid unwinds and separates into single-stranded strands
through the breaking of hydrophobic stacking attractions between the bases. The
process of DNA denaturation can be used to analyze some aspects of DNA and detect sequence differences between two different DNA
sequences.
Both
terms are used to refer to the process as it occurs when a mixture is heated,
although "denaturation" can also refer to the separation of DNA
strands induced by chemicals like urea.
Hybridization
occurs in all physiological DNA reactions including replication, and
transcription, and it forms the basis of many molecular biology techniques
including Southern and Northern blotting, PCR and sequencing and so on. This technique
has been applied to many aspects of human life, especially for biochemical and
clinical research fields.
Creative
Bioarray’s E-308 Hybridization system is one of the most advanced equipments in
molecular biology. With programmable and humidifying system, it
automates the steps in a slide-based FISH procedure, and provides walk-away
convenience for clinical and research personnel. It is also very easy to operate.
For example, up to 12 slides can be easily added or removed with one hand. Besides,
its two-side heating of slides allows for achieving exact and prompt correspondence
to the set and actual temperature and maintaining uniform temperature across
all slide positions.
Features
of E-308 Hybridization system：
Ÿ Touch
screen allows for easy to read, program and use
Ÿ It
can run In-situ PCR experiments
Ÿ Possibility
to export cycles data via USB memory
Ÿ Four
operation modes: denaturation/hybridization, hybridization fixed temperature,
custom, In-situ PCR
Ÿ Can
be used as a fixed temperature slide warmer
Ÿ Rapid
temperature ramp-up and accuracy of ±1°C
Ÿ Superior
temperature uniformity accross all slide positions
Ÿ Perfect
humidity control system
About
us
Creative Bioarray is a
well-recognized biotech company propelled by integrity, expertise and the
desire to contribute to simplify, improve, and accelerate research speed of the
scientists by providing the highest standard quality research products and
services. It provides products such as human tissue , animal tissue, tissue array,
microorganisms, cells, probes and services like cell services, biosample services,
histology services.
More
information at http://www.creative-bioarray.com/Equipments/E-308-Hybridization-system.htm
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