The MS-5 Cells and MS-5 Cell Line Used In Research

Creative Bioarray

The MS-5 cell is one kind of murine stromal cells, generated by irradiation of adherent cells in long-term bone marrow cultures. It was first established in 1989. MS-5 stromal cells are known to support the growth of hematopoietic stem cells and other cell types.





MS-5 cells can produce extracellular matrix proteins. The cells produce GM-CSF, and high quantities of IL6 and SCF. They also express HGF and the receptor and elaborate an activity that behaves like IL3. Research has proved that MS 5 cells support the growth of hematopoietic stem cells and granulocyte-macrophage colony-forming cells and moreover, conditioned medium of MS-5 cells can stimulate colony formation of granulocytes from murine bone marrow cells in semi-solid culture.



MS-5 cells support expansion of early human hematopoietic progenitor cells without need of exogenous growth factors . The expansion of primitive hematopoietic progenitor cells (HPC) need to be stimulated by growth factors and therefore, for many years the expansion of primitive hematopoietic progenitor cells remain to be a very challenging and complicated process. But recently researches use MS-5 cells to explore the role of stromal cell coculture for maintenance of progenitor/stem cell potentia and the research show the generation of GF producing murine stromal cells such as MS-5 cells can efficiently support expansion of early hematopoiesis without the adding extra GF.



Creative Bioarray maintains various human and animal cell lines that are invaluable for medical, scientific and pharmaceutical institutions and consistently attains the highest standards and uses the most reliable procedures to verify every cell line. The company provide MS-5 cells and MS-5 cell line established by irradiation of the adherent cells in long-term bone marrow cultures derived from C3H/HeNSlc strain mice. The MS-5 cells and MS-5 cell line are well preserved and are well suited for research use.



You can get MS-5 cells and MS-5 cell line at

http://www.creative-bioarray.com/MS-5-CSC-C2763-item-1619.htm